L'ensemble que forment ces contributions porte sur les différentes périodes et questions dont Jean Salem était lui-même spécialiste, ou les aborde par des biais inattendus : l'atomisme et l'épicurisme de l'Antiquité, la philosophie classique et le matérialisme des Lumières, le matérialisme moderne et ses critiques, la tradition marxiste, le pragmatisme, la pensée économique, la philosophie du vin ou encore la lecture philosophique des œuvres littéraires. Ce volume propose ainsi un aperçu de l'état des recherches sur le matérialisme, sous ses (...) différentes formes et dans ses interactions avec les autres traditions philosophiques."--Page 4 of cover. (shrink)

This study examined the laboratory dream content reported by 14 patients with schizophrenia and 15 controls, with a focus on reports obtained from NonREM sleep. Both the controls’ and patients’ frequency of dream recall following awakenings from NonREM and REM sleep were similar to values reported for healthy participants. Patients’ NonREM sleep narratives were shorter than those from controls. When compared to their reports from REM sleep, both groups’ NonREM sleep reports included significantly fewer words and reportable items. The controls (...) were more likely to report a subjective feeling of bizarreness for their REM sleep reports as compared to their NonREM sleep reports. This difference was not observed in patients with schizophrenia. Taken together, these findings suggest few differences between the NonREM sleep mentation of patients with schizophrenia and of controls and that sleep stage cognitive style is comparable in both groups, with NonREM sleep reports being more thought-like, less elaborate and bizarre than REM sleep reports. (shrink)

Drug exceptional access programs (DEAPs) exist across Canada to address gaps in access to pharmaceuticals. These programs circumvent standard procedures, raising epistemic, economic, social and political issues. This commentary provides insights into these issues by revealing the context and procedures on which these programs depend.

Devant le constat du déclin toujours plus rapide de la diversité biologique et les limites des res- sources disponibles pour l’enrayer, il est nécessaire de déterminer quels moyens devraient être engagés dans sa protection. Pour ce faire, une méthode efficace serait d’évaluer les bénéfices tirés de la biodiversité afin d’estimer rationnellement les coûts légitimes de sa protection. L’évaluation économique, qui se présente d’emblée sur un mode quantitatif, serait alors un outil précieux. Dans ce texte, nous présentons différentes méthodes d’évaluation économique (...) de la biodiversité ainsi que certaines de leurs limites méthodologiques. Par la suite, nous montrons qu’en dépit de ses avantages pratiques, l’évaluation économique échoue à représenter l’ensemble des valeurs en jeu dans la protection de la biodiversité. Nous décrivons alors trois types de valeurs incommen- surables avec des bénéfices économiques : la valeur de legs, qui renvoie aux obligations de trans- mission du patrimoine naturel dont nous avons hérité ; la valeur d’existence, qui renvoie à la considération morale d’intérêts autres que ceux des êtres humains ; la valeur de transformation, qui renvoie à la capacité d’examiner et de critiquer nos préférences et inclinaisons afin d’inclure celles-ci dans une vision du monde rationnelle et cohérente. Pour conclure, nous plaidons en faveur de l’élaboration de méthodes de concertation et d’évaluation participatives et pluralistes permettant de rendre compte de la diversité et de l’hétérogénéité des valeurs de la biodiversité. (shrink)

On a longtemps rendu compte des comportements de déplacements des hommes dans l’espace par un terme renvoyant à une logique collective et de masse, celui de migration . L’intégration dans l’observation et la compréhension de toute la palette des motifs de déplacements et l’individualisation croissante des pratiques ont amené l’usage d’un terme plus générique, emprunté aux sciences sociales et notamment à ceux qui s’intéressent à la fluidité dans l’espace social, celui de mobilité. Ce glissement n’est pas purement sémantique : il (...) exprime le passage de l’empire de la nécessité aux capacités stratégiques et aux désirs des acteurs, de la représentation aréolaire d’un territoire rassemblant une « société locale » « contenant » les déplacements de ses membres à des représentations réticulaires , multi-territoriales . Sur tous ces points, les enquêtes initiées dans les années 1960 par les ingénieurs pour alimenter leurs modèles de trafic nous ont permis, grâce à l’élaboration d’indicateurs, de concepts, de représentations nouvelles, de comprendre en profondeur la dynamique et les rôles respectifs des rationalités individuelles et de la formation de normes sociales dans le champ spécifique de la mobilité quotidienne. C’est de cette construction dont nous rendons compte dans cet article, qui livre aussi à partir des quelques résultats saillants des recherches conduites, les convictions fortes en matière de dynamique de la mobilité qui s’en dégagent et les paradigmes qu’il conviendrait de mieux explorer.Spatial behaviour was studied in the past through group concepts, such as residential or regular migrations from home to work. The will to understand travel behaviour for the full range of trip purposes and the growing personalisation of behaviour leads to adopt the term of mobility from social sciences. This change is not purely semantic. It expresses the transition from a vision based on the needs to the consideration of the strategic capabilities of the persons, from areola-based representations of a local society to network and archipelago-based representations of individual behaviours. We have used, in conjunction with the international community of travel behaviour analysts, the travel surveys introduced in the sixties to feed traffic models, to build concepts, indicators and representations of travel behaviour, to understand in depth the transformations of mobility patterns and to analyze the roles of individual rationality and social norms. The paper relates this history, highlights some key results and strong beliefs, and questions the need to explore new paradigms. (shrink)

Understanding the mechanisms and the time and spatial evolution of penumbra following an ischemic stroke is crucially important for developing therapeutics aimed at preventing this area from evolving towards infarction. To help in integrating the available data, we decided to build a formal model. We first collected and categorised the major available evidence from animal models and human observations and summarized this knowledge in a flow-chart with the potential key components of an evolving stroke. Components were grouped in ten sub-models (...) that could be modelled and tested independently: the sub-models of tissue reactions, ionic movements, oedema development, glutamate excitotoxicity, spreading depression, NO synthesis, inflammation, necrosis, apoptosis, and reperfusion. Then, we figured out markers, identified mediators and chose the level of complexity to model these sub-models. We first applied this integrative approach to build a model based on cytotoxic oedema development following a stroke. Although this model includes only three sub-models and would need to integrate more mechanisms in each of these sub-models, the characteristics and the time and spatial evolution of penumbra obtained by simulation are qualitatively and, to some extent, quantitatively consistent with those observed using medical imaging after a permanent occlusion or after an occlusion followed by a reperfusion. (shrink)

Virtue and the Moral Life brings together distinguished philosophers and theologians with younger scholars of consummate promise to produce ten essays that engage both academics and students of ethics. This collection explores the role virtues play in identifying the good life and the good society.

Virtue and the Moral Life brings together distinguished philosophers and theologians with younger scholars of consummate promise to produce ten essays that engage both academics and students of ethics. This collection explores the role virtues play in identifying the good life and the good society.

Clinical ethics committees (CECs) have been developing in many countries since the 1980s, more recently in the transitional countries in Eastern Europe. With their increasing profile they are now faced with a range of questions and challenges regarding their position within the health care organizations in which they are situated: Should CECs be independent bodies with a critical role towards institutional management, or should they be an integral part of the hospital organization? In this paper, we discuss the organizational context (...) in which CECs function in Europe focusing on five aspects. We conclude that in Europe clinical ethics committees need to maintain a critical independence while generating acceptance of the CEC and its potential benefit to both individuals and the organization. CECs, perhaps particularly in transitional countries, must counter the charge of “alibi ethics”. CECs must define their contribution to in-house quality management in their respective health care organization, clarifying how ethical reflection on various levels serves the hospital and patient care in general. This last challenge is made more difficult by lack of consensus about appropriate quality outcomes for CECs internationally. These are daunting challenges, but the fact that CECs continue to develop suggests that we should make the effort to overcome them. We believe there is a need for further research that specifically addresses some of the institutional challenges facing CECs. (shrink)

Introduction : Dialogue et diatribe, influences réciproques -- Réflexion théorique et construction d'outils d'analyse antique et moderne -- La prétendue "diatribe" antique : fantôme ou instrument herméneutique ? -- Diatribè, quelques jalons dans l'histoire d'un mot controversé -- Le style diatribe dans les Diatribai d'Épictète/Arrien -- "Que bel harnais ne fait pas bon cheval" : un topos de la philosophie morale et "populaire" entre dialogue, diatribe et protreptique -- Manipulations horatiennes de la diatribe cynico-stoïcienne dans les Satires : reprises et (...) mises à distance -- Du dialogue lucianesque à la diatribe philosophique : le Charon de Giovanni Pontano -- Diatribe et dialogisme : La voix de l'autre, quelle place et quelle voix accorder à l'interlocuteur ? -- Interrogatoire judiciaire et interrogation dialectique en partant d'Aristote, Rhétorique III 18 -- "Le partage des voix" dans les Entretiens d'Épictète -- La fonction de l'adresse dans le De Ira de Sénèque -- Le dialogue en échec chez Dion de Pruse -- Diatribe et Sermon, une fausse question ? -- Étude des dialogues fictifs dans quelques sermons d'Augustin. (shrink)

"This volume assembles twelve texts published between 1892 and 1915.... The editors allow one to see the genesis of the ideas of Duhem, philosopher and historian, of the variety of his styles, and sometimes also the limits of his work.... A useful index, probably unique in the field of Duhemian studies, completes the book.... The English-language public may be assured an exemplary translation and a reliable critical apparatus." --Jean Gayon, _Revue d'Histoire des Sciences_.

Cancers rely on multiple, heterogeneous processes at different scales, pertaining to many biomedical fields. Therefore, understanding cancer is necessarily an interdisciplinary task that requires placing specialised experimental and clinical research into a broader conceptual, theoretical, and methodological framework. Without such a framework, oncology will collect piecemeal results, with scant dialogue between the different scientific communities studying cancer. We argue that one important way forward in service of a more successful dialogue is through greater integration of applied sciences (experimental and clinical) (...) with conceptual and theoretical approaches, informed by philosophical methods. By way of illustration, we explore six central themes: (i) the role of mutations in cancer; (ii) the clonal evolution of cancer cells; (iii) the relationship between cancer and multicellularity; (iv) the tumour microenvironment; (v) the immune system; and (vi) stem cells. In each case, we examine open questions in the scientific literature through a philosophical methodology and show the benefit of such a synergy for the scientific and medical understanding of cancer. (shrink)

The genetically manipulated organism crisis demonstrated that technological development based solely on the law of the marketplace and State protection against serious risks to health and safety is no longer a warrant of ethical acceptability. In the first part of our paper, we critique the implicitly individualist social-acceptance model for State regulation of technology and recommend an interdisciplinary approach for comprehensive analysis of the impacts and ethical acceptability of technologies. In the second part, we present a framework for the analysis (...) of impacts and acceptability, devised—with the goal of supporting the development of specific nanotechnological applications—by a team of researchers from various disciplines. At the conceptual level, this analytic framework is intended to make explicit those various operations required in preparing a judgement about the acceptability of technologies that have been implicit in the classical analysis of toxicological risk. On a practical level, we present a reflective tool that makes it possible to take into account all the dimensions involved and understand the reasons invoked in determining impacts, assessing them, and arriving at a judgement about acceptability. (shrink)

Conscious awareness comprises two distinct states, autonoetic and noetic awareness. Schizophrenia impairs autonoetic, but not noetic, awareness. We investigated the strategic regulation of relevant and irrelevant contents of conscious awareness in schizophrenia using a directed forgetting paradigm. Twenty-one patients with schizophrenia and 21 normal controls were presented with words and told to learn some of them and forget others. In a subsequent test, they were asked to recognize all the words they had seen previously and give remember, know or guess (...) responses according to whether they recognized words on the basis of autonoetic awareness, noetic awareness, or guessing. Overall, patients showed the same degree of a directed forgetting effect as normal subjects. However, whereas the effect was observed both for remember and know responses in normal subjects, it was observed for know, but not for remember, responses in patients. These results indicate that patients with schizophrenia exhibit an impaired strategic regulation of contents of autonetic awareness for relevant and irrelevant information. (shrink)